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p53 Pathway, p53 induces the expression of PUMA, E2F induces the expression of Cyclin E, Cyclin E is degraded into p18(CycE), p53 induces the expression of p21, Cyclin E join to form Cdk2/Cyclin E, p53 induces the expression of Bax, p53 induces the expression of Bid, p19(ARF) phosphorylate (inhibits) MDM2, p53 induces apoptosis, Cdk2/Cyclin E promotes G1/S Transition